Computation & Neural Systems California Institute of Technology

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image Carlos Lois
Research Professor

phone: 626-395-1579

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Our laboratory investigates the mechanisms by which the coordinated activity of neurons connected to each other in circuits gives rise to brain function. To address this issue we focus on three complementary questions: (i) what is the wiring diagram of the connections that link neurons together in a circuit?, (ii) how does information flow through a neuronal circuit?, and (iii) what are the mechanisms by which the function of brain circuits remains reliable despite noise?.  To investigate these questions we are developing new genetic technologies to identify neuronal connectivity, to manipulate the biophysical properties of neurons, and to record their dynamics. In addition, we use electrophysiological methods to study neuronal activity in single cells, and optical imaging methods to record the activity of large numbers of neurons in behaving animals.

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  last update: 05/20/2019
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